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Saturday, 25-Feb-2012 10:13 Email | Share | | Bookmark
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Friday, 17-Feb-2012 08:01 Email | Share | | Bookmark
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Monday, 6-Feb-2012 01:04 Email | Share | | Bookmark
online pharmacy discount Global Cancer Market Review 2008 (World

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National Most cancers Institutecis platinum Crystals

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Copied from http//workplace.microsoft.comClip art and Picture Assortment






Introduction (Common inall International Marketplace ---Reviewknols) Techniques and Data Collection (Common inall Global Current market ---Reviewknols)

Effects and Discussion (Para one and two Prevalent inall International Marketplace ---Reviewknols)

Even more looking at and References

Viewers are encouraged to very first examine the lead knol in the sequence for history introduction, methodology employed, references and common discussion portions.


International Pharmaceutical Marketplace Overview & Globe Top rated 10/Twenty Medications 2008


The monograph is the distinctive resource of summary of every Industry Report in one location

Worldwide Current market Intelligence Monograph 2009


Comprehending Most cancers-- A Countrywide Institute of Most cancers Slide Set

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http//www.most cancers.gov/cancertopics/understandingcancer/most cancers



NCI-Knowledge Cancer Slides

NCI-Understanding Cancer Slides






Most cancers Detection & Remedy



Detect and Picture X ray, MRI, CT, Ultrasound, PET, SPECT

Therapy

2. Radiation X ray, Gamma rays, Neutron, Focussed UltraSound, Laser,

two. Surgery Robotics, Microsurgery

three.Chemotherapy Cytotoxics Taxol, Camptothecins, Vinca, Tamoxifen, Cis platinum

4. Biologics

Cytokines Interleukins

Antibodies mAbs Avastin, Herceptin, Rituxan

Vaccines Gardasil, Cervarix

RNAi, Antisense Vitravene

Apoptosis

Angiogenesis Erbitux

Gene suppression Glivec, Sutent, Sprycel, Tasigna

























Anticancer Drugs Mode of Action

Anticancer Medications Mode of Action

Cancer Annual Fatalities WHO

International fatalities for each year 7.6 million in 2008

Lung cancer one.3 million

Belly Most cancers 803000

Colorectal 639000

Liver Cancer 610000



forty% of cancer fatalities are preventable


A new analyze estimates the world wide load of most cancers at 895 billion bucks in 2008 equivalent to one.5% of world's GDP. Around seventy five% of the cancer fatalities are in weak and establishing nations which account for 56% of new cancer individuals for each year. Only 5% of the resources are accessible to fight cancer in the very poor countries.

Superstar misplaced to most cancers Pic App images Getty

Farraw Fawcett




Senator Ted Kennedy with President Obama




YouTube Video clip

Effects and Dialogue

The worldwide anticancer market place increased from $65 billion in 2007 to $70 billion in 2008 the moment once again a period of time of significant growth. The prime 3 market place leaders had been all monoclonal antibodies led by Rituxan, Herceptin and Avastin. All the outlined medication in table 1 had income of $two billion or much more. The variety of blockbuster anticancer medicines with income of $one billion or additional greater from 19 in 2007 to 24 in 2008. Patent expiry and generic introduction resulted in sales decline for Eloxatin. Due to the fact past two many years, cancer has turn into the 3rd massive therapeutic market right after cardiovascular ($95 billion) and central nervous method drugs ($87 billion).

FDA rejected many higher profile most cancers medication during the past two several years and asked for extra data including survival advantages in clinical trials prior to approval. The victims ended up GPC Biotech/Spectrum oral platinum analog Setraplatin and two most cancers vaccines from Antigenics (OncophageTM) and Dendreon (ProvengeTM). The oncology advisory committee had recommended the approval of Provenge. Oncophage was authorized and released in Russia in late 2008. Many other vaccines are in Cycle II-III trials like Onyvax, Lovaxin, BioVax and NeuVax. Various cancer vaccines like Panvac, Canavaxin and MyVax ended up terminated because of online pharmacy discount to very poor Phase III outcomes. Of the thirteen new cancer drugs accredited due to the fact 2005, Gardasil reached blockbuster revenue in 2007, 3 medicines Nexavar, Femara and Sutent had product sales of around $ one billion in 2008 alongside with Revlimid and Velcade which had been accepted in 2004. FDA accepted two new cancer medications in 2008, Sancuso of ProStreaken for nausea and vomiting and Treanda of Cephalon for Serious Lymphocytic Leukemia. FDA had authorized five new most cancers medications in 2007 and four in 2006.


Most cancers R&D is the driving power guiding several biotechnology business start out ups and account for a extremely large reveal of the R&D finances as well as variety of assignments. PhRMA Adis website lists about 750 most cancers medicine in R&D and clinical trials. There are a number of Gleevec, Avastin and Herceptin adhere to up drugs (selective kinase inhibitors, monoclonal antibodies) in Phase III trials.Commercial good results of Gleevec has led to three approved followup drugs and additional one particular Brivanib from BMS submitted for FDA approval. Axitinib from Pfizer is a tyrosine kinase receptor and VEGF one inhibitor. Pazopanib like Avastin is a VEGF2 and PDGFR inhibitor. Afinitor (Everolimus) an mTOR inhibitor from Novartis was submitted for approval in renal cell carcinoma and is accepted for kidney transplant. Pfizer/ImClone human monoclonal antibody Ramicirumab is in Phase III trials as a adhere to up Avastin. With so numerous promising drug candidates in Phase III trials it is not possible to present a extensive overview.Ixempra (Ixabepilone, BMS) an analog of Epothiolone (microtubule inhibitor) was authorized by FDA in 2007 for breast cancer and PharmaMar orphan drug Yondelis (Trabectedin) was permitted to handle gentle tissue sarcoma in Europe. Trabectidin is a DNA binder and cell cycle inhibitor and is a synthetic analog of ecteinascidin isolated from the sea squirt.

Roche and Genentech are the leading most cancers firms by gross sales and R&D. Amgen, Novartis, Astra Zeneca, BMS and Pfizer are the other top most cancers companies by revenue and R&D. The long run progress of the current market will be established by freshly launched solutions. BMS is major its rivals with two recent approvals and one regulatory submitting.



YouTube Video clip



YouTube Video


Associated Most cancers Content


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Krishan Maggon/Krishan MAGGON's knols/ Ipilimumab (BMS) Evaluation A Cancer Breakthrough? / PLX 4032 (Plexxikon, Roche) Melanoma Review / Breast Cancer Multimedia Evaluation/ Denosumab (Xgeva, Amgen) Most cancers Review / Iniparib, Olaparib & Veliparib (PARPi) Breast Most cancers Evaluation / Ramucirumab (Lilly) Most cancers Critique / Zalutumumab (HuMax-EGFR, Genmab) Most cancers Assessment / Aurora Kinase Inhibitors Most cancers Overview / Farletuzumab ( Eisai) Most cancers Assessment / Cervarix (Glaxo Smith Kline) Vaccine for Cervical Most cancers / Gardasil (Merck) for Cervical Most cancers and Genital Warts / International Cancer Market Overview 2008 (World Top rated Ten Most cancers Drugs) / Cancer Collection /



Cervarix (Glaxo Smith Kline) pour Most cancers du col de l'utrus Ipilimumab (BMS) a examen a por el cncer?/ Le Ipilimumab (BMS) un remde magique contre le mlanome ?/

Acknowledgements

Many thanks are because of to Mr.Jean-Antoine de Mandato(PDP, Geneva) for offering workplace services and administrative assist.

National Most cancers InstituteTaxol Molecule Image ID 2540

http//visualsonline.most cancers.gov/details.cfm?imageid2540


Table 1. To Promoting Anticancer Manufacturers in 2008.

Gross sales $ billion

20072008

Global Cancer Market6570



Generic Title

Manufacturers



Organizations

Indications

Gross sales $ billion

2006 20072008
PA


Rituximab

Rituxan

Roche

NHL, RA

4.75.015.six


Trastuzumab

Herceptin

Roche

Breast Most cancers

3.144.44.8


Bevacizumab

Avastin

Roche

Colon Cancer

two.forty three.934.seven

Imatinib

Gleevec Glivec

Novartis

CML, GISTChronic Myelogenous Leukemia, GI Stromal Tumors

two.fifty three.13.four


Darbepoetin

Aranesp

Amgen

Anemia

four.14.two three.3


Docetaxel

Taxotere

Sanofi Aventis

Breast, Lung, Prostate, Gastric cancer

two.22.63.2


G-CSF

Neulasta

Amgen onlinepharmacynoprescriptionbako.com

Neutropenia

2.62.73.2


Human Papilloma Virus

Gardasil

Merck

Cervical Cancer

one.53.


Erythropoietin


Procrit Eprex


J&J

Anemia

3.22.ninety two.3


Erythropoietin

Epogen

Amgen

Anemia

two.52.sixty two.three


Anastrozole

Arimidex

Astra Zeneca

Breast Cancer

1.51.72.


Cetuximab

Erbitux

BMS, Merck AG

Colon Cancer, Head & Neck Cancer

1.11.352.

P ProjectedA Real income


National Cancer InstituteReed Sternberg Cell in Hodgkin Lymphoma

Picture ID 7172

http//visualsonline.cancer.gov/details.cfm?imageid7172

YouTube Video clip



Table two. Blockbuster Anticancer Makes and Freshly Permitted Medication 2008.


Generic Identify

Manufacturers



Organizations

Indications

Cancer Variety

Revenue $ billion

20072008
PA


Oxaliplatin

Eloxatine

Sanofi Aventis

Colon

2.131.6


Luprolide

Lupron

Takeda

Prostate

one.66


Gemcitabine

Gemzar

Lilly

Most cancers

1.6


Bicalutamide

Casodex

Astra Zeneca

Prostate

1.33


Zolidronic acid

Zometa

Novartis

Bone

1.30


Filgrastim

Neupogen

Amgen

Neutropenia

one.23


Groserelin

Zoladex

Astra Zeneca

Prostate

one.10


Somatostatin

Sandostatin

Novartis

Acromegaly

1.02


Capecitabine

Xeloda

Roche

Cancer

one.02


Irinotecan

Camptosar

Pfizer

Colon

.97


Sunitinib

Sutent

Pfizer

RCC, GIST

Letrozole

Femara

Novartis

Breast

.ninety three


Lenalidomide

Revlimid

Celgene

Numerous Myeloma

.771.3


Bortizomib

Velcade

Takeda

Several Myeloma

Desatinib

Sprycel

BMS

ALL, CML PhC

Nilotinib

Tasigna

Novartis

CML PhC

Pemetrexed

Alimta

Lilly

NSCLC, MPM

Panitumumab

Vectibix

Amgen

Colon

Ixabepilone

Ixempra

BMS

Breast

Azacitabine

Vidaza

Celgene

Anemia, MDS, AML

Sorafenib

Nexavar

Bayer/Onyx

RCC, HCC


P ProjectedA Exact gross sales

ALL Acute Lymphoblastic Leukemia , AML Acute Myeloid Leukemia

CML Persistent Myeloid Leukemia, PhCPhiladelphia Chromosome

HCC Hepato Mobile Carcinoma, RCC Renal Cell Carcinoma,

GIST Gastrointestinal Stromal Tumor

NSCLC Non Tiny Cell Lung Cancer

MPM Malignant Pleural Mesothelioma, MDS Multidysplastic syndrome



Cancer Medicines Guides and Monographs



Cancer Medicines Guides and Monographs

Most cancers Medication Guides and Monographs




Cancer Drug approvals and MED News/Breast Cancer/Gastrointestinal Cancer/Geriatric Cancer


Cancer Hyperlinks and Knols
Cancer Collection

Krishan Maggon

Krishan Maggon Knols



Market Research Reports


Click on the url


Krishan Maggon/Krishan MAGGON's knolsI Leading 10 Monoclonal Antibodies 2010 I Leading 10/20 Medicines 2008 I Prime 10/Twenty Very best Advertising Drugs 2009 I M&A Review Pharmaceutical & Biotechnology Industry I I High Priced Prescription Medications I Leading 10/Twenty Best Advertising Medicines 2010 I Stem Cell Treatment Industry I M&A Biotechnology I Knol Initially & Second Yr Odyssey I World-wide Vaccine Industry 2010 ITop Ten Monoclonal Antibodies 2010 I


World-wide Pharmaceutical Industry Assessment & Earth Top rated 10/20 Drugs 2008 I Global Cardiovascular Market Assessment 2008 (Earth Prime Ten CV Medicine) I Worldwide Monoclonal Antibodies Industry Review 2008 (Earth Best Ten mAbs) I World-wide Vaccine Industry Review 2008 (Entire world Prime Ten Vaccines) I Worldwide Market Intelligence Overview Monograph 2009 I World-wide Biotechnology Market Evaluation & Earth Best 10 Biotech Medicines 2008 I Global Cancer Current market Overview 2008 (Earth Top rated Ten Most cancers Medication) I Worldwide Brain Drugs Marketplace Review 2008 (Earth Best 10 CNS Medication) I Global Diabetes Market place Review 2008 & Earth Best 10 Diabetes medication I World wide Biologic Industry Overview & Prime 10 Biologics 2008 I World-wide Antiviral/Antibiotics Current market Assessment 2008 (Planet Top rated Ten Antimicrobial Agents) I World wide Angiotensin II Receptor Antagonists Market place Critique 2008 I Billion Greenback Generics & Global Generic Market Overview 2009 I World-wide Respiratory Market place Assessment & Earth Best Ten Respiratory Medication 2008 I Worldwide Pharmaceutical Current market Intelligence Monograph I World-wide Biotechnology Market Intelligence Monograph I Top Promoting Human Medical Brands of 2007 I


Influenza ( 2009 H1N1 ) Vaccine Current market I Influenza Antivirals Industry 2009 I Pharmaceutical and Biotechnology Market Overview 2009 I Top rated Selling Human Medicinal Brand name and Global Pharmaceutical Current market 2009 I Market place Research Reports Evaluation (Knowledge Discrepancies) I Vaccine Current market 2009 I




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Saturday, 21-Jan-2012 09:30 Email | Share | | Bookmark
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